A 62-year old male patient presents to his G. with a non-productive cough and hoarseness that has been ongoing for the last month.

A 62-year old male patient presents to his G.P. with a non-productive cough and hoarseness that has been ongoing for the last month. During the consultation the patient describes how he has had little appetite and has been feeling tired despite a reduction in his workload as a builder. He also discusses how he has been trying to cut down on his smoking from around 30 to 10 cigarettes per day as he has been feeling short of breath. Following a physical examination, the G.P. orders blood tests, sputum tests, and a chest X-ray. Further investigations, by CT scan and bronchoscopy, reveal a sizable mass within the left bronchus (the right lung was unremarkable).
Immunohistochemical markers CK5/6, CK7, TTF-1 and p63, are frequently used to confirm a diagnosis of adenocarcinoma of the lung. Explain the role of these markers in terms of differential expression, specificity and overall contribution to diagnosis.
 
“Looking for a Similar Assignment? Get Expert Help at an Amazing Discount!”

"Is this question part of your assignment? We will write the assignment for you. Click order now and get up to 40% Discount"